Gemfibrozil, a lipid-lowering drug, improves damage in a mouse model of aging
It’s interesting that Kennedy now says that it’s only gemfibrozil, of the Fibrate family, that has life extending properties, and that it has nothing to do with it’s PPAR-alpha properties....
View ArticleAcarbose - Details On Another Top Anti-Aging Drug
Yes, I wait until I’m having a meal with some carbs and I take 100. Sometimes it’s only once a week…
View ArticleThe Effective and Safe Supplements / Medications Today
That’s right, then sorbitol dehydrogenase converts sorbitol to fructose for metabolism. It’s been over a decade+ since I worked in the project so my memory is a little hazy but I think there were rate...
View ArticleCoversion of ppm to mg or mg/kg
@AlexKChen This was very useful information on rapa dosing. Thanks.
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Rapamycin: The Gift that Keeps on Giving
Merry Christmas to you all. You are a wonderful and warm community that I’m so grateful to be a part of. Have learned (and implemented) so much! Wishing all a healthy, happy and prosperous 2024!
View ArticleFucoidans (SIRT6 activators) from brown algae. Where to source?
https://www.linkedin.com/in/reissjones?utm_source=share&utm_campaign=share_via&utm_content=profile&utm_medium=android_app
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Rapamycin: The Gift that Keeps on Giving
Happy Christmas to one and all. I was one of those few who had ‘zero presence’ on the internet until this year….but I was so enamoured by this forum (both by its members and moderator @RapAdmin), that...
View ArticleRapamycin (or acarbose/empagliflozin) and waist circumference
For the PEARL trial, I’d first refer everyone to PEARL Trial to Prolong Life With Longevity Products | AgelessRx and to CTG Labs - NCBI where the study design and endpoints are described. This was a...
View ArticleAcarbose - Details On Another Top Anti-Aging Drug
I take 50 mg right before my berries-apple-yoghurt sallad.
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Coversion of ppm to mg or mg/kg
Just stumbled upon this drug dosing calculator - for going from animals to humans… Drug Hunter Practical PK Calculators This page contains practical PK calculators useful for day-to-day drug...
View ArticleGemfibrozil, a lipid-lowering drug, improves damage in a mouse model of aging
The study I saw showed less than 1% getting muscle problems from gemfibrozil. A significant minority gets this from statins.
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Strategies for Tolerating Rosuvastatin
Not a recommendation, as I am not a doctor, but you could try Pravastatin, one of the least diabetogenic of the statin family. The BMJ – 23 May 13 Risk of incident diabetes among patients treated with...
View ArticleStrategies for Tolerating Rosuvastatin
Digging into the above "Transporters for the Intestinal . . . " article gets a little wonky but the takeaway is that ezetimibe does interfere with the intestinal absorption of tocopherols and...
View ArticleStrategies for Tolerating Rosuvastatin
@LaraPo, Were you able to judge the contribution of pantethine to your reduced LDL? The studies I have read are all positive but one notes that it can take six to 12 months to gain full effect.
View ArticleAnyone taking Nattokinase? Why not?
Amen !! As an ER physician, I am so tired of folks advocating for conclusive RCTs before recommending a supplement that has no downside.
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Dump my Resveratrol?
This paper seems to support low dose Resveratrol (100mg) for people with MTHFR mutation. Given what was found in this study it would appear to me that anyone with potential CVD risks could potentially...
View ArticleAcarbose - Details On Another Top Anti-Aging Drug
I take 50mg with every meal when I remember. At least once per day and usually twice.
View ArticleStrategies for Tolerating Rosuvastatin
I’m not taking it that long, may be 3 mo the most, but my LDL went down to a normal level. I’ll definitely continue with it and remeasure lipids in May.
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Has anyone tried tFUS (ultrasound) to reduce plaques or for cognitive...
PubMed Central (PMC) Transcranial focused ultrasound, pulsed at 40 Hz, activates microglia acutely... Iaccarino et al [] exposed one hour of light flickering at 40 Hz to awake 5XFAD Alzheimer’s...
View ArticleHas anyone tried Rupa Health for ordering labs?
eg cf Interpreting Oxidative Stress Markers
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